Mathematical analysis of HIV infection of CD4+ T-cells with discrete delays

Abstract

In this study, we introduce a discrete time to the model to describe the time delays between infection of a CD4+ T-cells, and the emission of viral particles on a cellular level. We begin by determining the existence and stability of the equilibrium. Further We investigate the global stability of the infection-free equilibrium and give sufficient condition for the local stability of the infected steady state is asymptotically stable for all delays. Finally, the numerical simulations are presented to illustrate the analytical results.