The effect of immune responses in HCV disease progression

Abstract

In this research article, the discreet role of Cytotoxic T Lymphocyte (CTL) during the Hepatitis C Virus infection has been studied. To explore the implications of the CTL responses, we have formulated a model considering the dynamics of the population of uninfected liver cells, infected liver cells, HCV and CTL responses. Since the actual incidence rate is probably not linear over the entire range of virus and uninfected liver cells. So, here we have assumed that there exists a saturation effect in disease transmission rate. We have analysed the model by both analytical as well as numerical approaches. We have found out the threshold condition that determines the existence and stability of the endemic equilibrium.